The disease results in emaciation and death if left untreated. ∙ Simmonds disease is a chronic deficiency of function of the pituitary gland, a form of hypopituitarism, that leads to atrophy of many of the viscera, including the heart, liver, spleen, kidneys, thyroid, adrenals, and gonads. This disease is known as Addison's disease. This results in vomiting, diarrhoea and skin pigmentation. ∙ Insufficient secretion of aldosterone from the adrenal cortex leads to low plasma sodium ,high potassium and increased excretion of sodium through urine. ditions which call forth accelerated activity on thepart of the gland, and to examine how an animal lacking adrenal hormones fares in the same conditions. The adrenal cortex apoptosis analysed by in situ end labelling of fragmented apoptotic nuclei DNA (TUNEL) showed that the highest apoptotic index was detected. produces hormones that are vital to life, such as cortisol (which helps regulate metabolism and helps your body respond to stress) and aldosterone (which helps control blood pressure). Each one is divided into the adrenal cortex (or outer layer) and the medulla (or inner layer).

∙ When adrenal cortex secretes more aldosterone due to formation of tumour on the gland ,it results in high plasma sodium ions,low plasma potassium ion,rise in blood volume ,high blood pressure and polyurea. The Adrenal Glands are located just above each of the kidneys. ∙ Hypersecretion of adrenal glands leads to cushing's disease which is caused due to excessive cortisol secretion characterised by high blood sugar,high plasma sodium,low potassium ,obesity ,high blood pressure and volume.

Adrenal cortex activity